Resources and useful documents

Regulatory context

• American Congress of Obstetricians and Gynecologists (ACOG): http://www.acog.org/
• Society for Maternal–Fetal Medicine (SMFM): https://www.smfm.org/

Scientific papers

Lo YM, Tein MS, Lau TK, et al. Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am J Hum Genet. 1998;62(4):768-75.

Norton ME, Brar H, Weiss J, et al. Non-Invasive Chromosomal Evaluation (NICE) Study: results of a multicenter prospective cohort study for detection of fetal trisomy 21 and trisomy 18. Am J Obstet Gynecol. 2012 Aug;207(2):127.e1-8. doi: 10.1016/j.ajog.2012.05.021. Epub 2012 Jun 1. PubMed PMID: 22742782.

Bianchi DW, Platt LD, Goldberg JD, et al. MatErnal BLood IS Source to Accurately diagnose fetal aneuploidy (MELISSA) Study Group. Genome-wide fetal aneyploidy detection by maternal plasma DNA sequencing. Obstet Gynecol. 2012;119(5):890-901.

Patricia A. Taneja, Holly L. Snyder, Eileen de Feo, Kristina M. Kruglyak, Meredith Halks-Miller, Kirsten J. Curnow and Sucheta Bhatt

Non-invasive prenatal testing in the general obstetric population: clinical performance and counseling considerations in over 85000 cases†. Prenat Diagn. 2016 Mar; 36(3): 237–243.

†Data was previously presented as an oral presentation at the Fetal Medicine Foundation (FMF),14^th World Congress in Fetal Medicine, Crete, Greece, June 21–25, 2015.

Scientific information

• Focus 51-INTGB: Non-invasive prenatal testing for trisomies 13, 18 and 21

Practical documents

• B39-INTGB : Request form for Ninalia NIPT test
• D39-INTGB : Declaration of Ninalia NIPT information and consent
• K39P-INTGB : Protocol for Ninalia NIPT sampling

Information leaflet for Ninalia NIPT

• Expectant parents leaflet
• Healthcare providers leaflet