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Ninalia NIPT The prenatal trisomy screening test based on maternal blood sample

Your most frequent questions

Who is NIPT for?

Eurofins Biomnis follows the international recommendations of the American Congress of Obstetricians and Gynecologists (ACOG) and the Society for Maternal–Fetal Medicine (SMFM) with regard to the non-invasive prenatal testing of high-risk patients, namely:

  • Risk greater than 1/1000 based on maternal serum screening
  • Maternal age ≥ 38 years for patients who have not benefited from maternal serum screening
  • History of pregnancy with foetal chromosomal abnormality
  • Parent who is a carrier of a Robertsonian translocation involving chromosome 13 or 21
  • Twin pregnancies
  • 1st line screening

Please contact Eurofins Biomnis at international@biomnis.com for any information on Ninalia NIPT outside the scope of these main recommendations mentioned above.

When can Ninalia NIPT be conducted?

Ninalia NIPT can be carried out at any point in the pregnancy from Week 10 (gestational age).

What are the performance data for Ninalia NIPT?

Since October 2014, Eurofins Biomnis has chosen to collaborate with the company Illumina, a world leader in DNA sequencing, for non-invasive screening for the main chromosomal abnormalities.

The new VeriSeq NIPT method offers the best performance for non-invasive screening for the main chromosomal abnormalities.

Sensibility / Specificity
*Data from the supplier Illumina, February 2017. Down syndrome 99%* 99,9%* Sensitivity Specificity

How to prescribe Ninalia NIPT?

The following documents are needed to conduct Ninalia NIPT:

Report from the 1st trimester ultrasound

How is the sample collected?

This sample requires 1 specific “Streck” tube.

Sample type: whole blood (1 x 10 mL).

How are the results returned?

The results are reported directly to the physician who prescribed the test within a period of 5 working days – Monday to Friday from sample receipt at Eurofins Biomnis.

What are the limits of Ninalia NIPT?

Eurofins Biomnis follows the International recommendations of the American Congress of Obstetricians and Gynecologists (ACOG) and the Society for Maternal–Fetal Medicine (SMFM).

Ninalia NIPT is not intended to detect:

  • Unbalanced translocations, microdeletions, microduplications
  • Mutations causing other diseases
  • Neural tube defects
  • Cases of triploidy

Is there a risk of false positive and false negative results?

Rare cases of false positives and false negatives have been described in the following contexts:

Mosaicism Chromosome variants Low foetal DNA fraction Placental mosaicism Vanishing twin Chromosome variants In exceptional cases:maternal mosaicism / neoplasia False negative False positive

Ninalia NIPT currently offers the best performance for non-invasive screening for the main chromosomal abnormalities.

I have not found the answer to my question: who can I contact?

The laboratory specialists approved for prenatal diagnostics and responsible for Ninalia NIPT at Eurofins Biomnis are available to work with you to ensure the best possible implementation of this test, from assessment of the relevance of the test in consideration of the patient’s files, to reporting the results.

You can contact Eurofins Biomnis at international@biomnis.com

Does your laboratory have the necessary authorisations to carry out this test?

Eurofins Biomnis is authorised by the Regional Health Authority to perform prenatal diagnostics and has all of the licences necessary for the conduct of this genetic test.

Eurofins Biomnis: who are we?

European leader in the sector of specialized medical pathology, Eurofins Biomnis carries out over 32,000 analyses per day from a range of over 2,500 available tests, including specialized tests for which the company has the appropriate authorizations.

Founded in 1897 by Marcel Mérieux, Eurofins Biomnis remains the leader in the field of specialized medical pathology in France. It has kept its position through continuous technological innovation and investment, particularly in areas such as female biology, oncology and personalized medicine, as well as chromosomal and molecular genetics.

With 120 years of expertise and innovation in the service of medical pathology, Eurofins Biomnis is the core of the Clinical Diagnostics division in Europe and has its eyes set on its international development.

Find your nearest testing centre As Ninalia NIPT requires a specific sample tube, don’t forget to make an appointment in advance with your local laboratory for specimen collection.

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